Blackmailed into dealing with Dr. Dorothy's little "plumbing problem," a shrunken Manny and Doug must eliminate the "Clogoids" or risk losing their jobs. As they negotiate the bowels of TerroMax, Inc., narrowly avoiding poo monsters and suspicious culinary fare, they discover another side to the story: the Destructomites!

The Colgoids assist Manny in rescuing Doug from the poo monster